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New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins

Oxidized bases in the mammalian genome, which are invariably mutagenic due to their mispairing property, are continuously induced by endogenous reactive oxygen species and more abundantly after oxidative stress. Unlike bulky base adducts induced by UV and other environmental mutagens in the genome t...

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Detalhes bibliográficos
Publicado no:Cell Mol Life Sci
Main Authors: Dutta, Arijit, Yang, Chunying, Sengupta, Shiladitya, Mitra, Sankar, Hegde, Muralidhar L.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Basel 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395533/
https://ncbi.nlm.nih.gov/pubmed/25575562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-014-1820-z
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