Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions

Ionizing radiation (IR) induces highly cytotoxic double-strand breaks (DSBs) and also clustered oxidized bases in mammalian genomes. Base excision repair (BER) of bi-stranded oxidized bases could generate additional DSBs as repair intermediates in the vicinity of direct DSBs, leading to loss of DNA...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Hegde, Muralidhar L., Dutta, Arijit, Yang, Chunying, Mantha, Anil K., Hegde, Pavana M., Pandey, Arvind, Sengupta, Shiladitya, Yu, Yaping, Calsou, Patrick, Chen, David, Lees-Miller, Susan P., Mitra, Sankar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342353/
https://ncbi.nlm.nih.gov/pubmed/27303920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9914
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