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Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
Among several reversible epigenetic changes occurring during transcriptional activation, only demethylation of histones and cytosine-phosphate-guanines (CpGs) in gene promoters and other regulatory regions by specific demethylase(s) generates reactive oxygen species (ROS), which oxidize DNA and othe...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7486736/ https://ncbi.nlm.nih.gov/pubmed/32826329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919445117 |
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