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Endothelial-Derived Oxidative Stress Drives Myofibroblastic Activation and Calcification of the Aortic Valve

AIMS: Oxidative stress is present in and contributes to calcification of the aortic valve, but the driving factors behind the initiation of valve oxidative stress are not well understood. We tested whether the valve endothelium acts as an initiator and propagator of oxidative stress in aortic valve...

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Pubblicato in:PLoS One
Autori principali: Farrar, Emily J., Huntley, Geoffrey D., Butcher, Jonathan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395382/
https://ncbi.nlm.nih.gov/pubmed/25874717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0123257
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