Side-Specific Endothelial-Dependent Regulation of Aortic Valve Calcification: Interplay of Hemodynamics and Nitric Oxide Signaling

Arterial endothelial cells maintain vascular homeostasis and vessel tone in part through the secretion of nitric oxide (NO). In this study, we determined how aortic valve endothelial cells (VEC) regulate aortic valve interstitial cell (VIC) phenotype and matrix calcification through NO. Using an anc...

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Main Authors: Richards, Jennifer, El-Hamamsy, Ismail, Chen, Si, Sarang, Zubair, Sarathchandra, Padmini, Yacoub, Magdi H., Chester, Adrian H., Butcher, Jonathan T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2013
Assuntos:
Regular Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644712/
https://ncbi.nlm.nih.gov/pubmed/23499458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.01.037
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