A Novel Tricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor, GRL-0739, Effectively Inhibits the Replication of Multidrug-Resistant HIV-1 Variants and Has a Desirable Central Nervous System Penetration Property In Vitro

We report here that GRL-0739, a novel nonpeptidic HIV-1 protease inhibitor containing a tricycle (cyclohexyl-bis-tetrahydrofuranylurethane [THF]) and a sulfonamide isostere, is highly active against laboratory HIV-1 strains and primary clinical isolates (50% effective concentration [EC(50)], 0.0019...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Amano, Masayuki, Tojo, Yasushi, Salcedo-Gómez, Pedro Miguel, Parham, Garth L., Nyalapatla, Prasanth R., Das, Debananda, Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394833/
https://ncbi.nlm.nih.gov/pubmed/25691652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04757-14
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