Synthesis of a Sugar-Based Thiosemicarbazone Series and Structure-Activity Relationship versus the Parasite Cysteine Proteases Rhodesain, Cruzain, and Schistosoma mansoni Cathepsin B1

The pressing need for better drugs against Chagas disease, African sleeping sickness, and schistosomiasis motivates the search for inhibitors of cruzain, rhodesain, and Schistosoma mansoni CB1 (SmCB1), the major cysteine proteases from Trypanosoma cruzi, Trypanosoma brucei, and S. mansoni, respectiv...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Fonseca, Nayara Cristina, da Cruz, Luana Faria, da Silva Villela, Filipe, do Nascimento Pereira, Glaécia Aparecida, de Siqueira-Neto, Jair Lage, Kellar, Danielle, Suzuki, Brian M., Ray, Debalina, de Souza, Thiago Belarmino, Alves, Ricardo José, Júnior, Policarpo Ademar Sales, Romanha, Alvaro José, Murta, Silvane Maria Fonseca, McKerrow, James H., Caffrey, Conor R., de Oliveira, Renata Barbosa, Ferreira, Rafaela Salgado
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Chemistry; Biosynthesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394791/
https://ncbi.nlm.nih.gov/pubmed/25712353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04601-14
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