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Anesthetics Target Interfacial Transmembrane Sites in Nicotinic Acetylcholine Receptors
General anesthetics are a heterogeneous group of small amphiphilic ligands that interact weakly at multiple allosteric sites on many pentameric ligand gated ion channels (pLGICs), resulting in either inhibition, potentiation of channel activity, or both. Allosteric principles imply that modulator si...
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| Udgivet i: | Neuropharmacology |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394016/ https://ncbi.nlm.nih.gov/pubmed/25316107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.10.002 |
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