Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain

An extensive search for isoflurane binding sites in the nicotinic acetylcholine receptor (nAChR) and the proton gated ion channel from Gloebacter violaceus (GLIC) has been carried out based on molecular dynamics (MD) simulations in fully hydrated lipid membrane environments. Isoflurane introduced in...

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Detaylı Bibliyografya
Asıl Yazarlar: Brannigan, Grace, LeBard, David N., Hénin, Jérôme, Eckenhoff, Roderic G., Klein, Michael L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2010
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922517/
https://ncbi.nlm.nih.gov/pubmed/20660787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1008534107
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