In vivo genome editing using Staphylococcus aureus Cas9

The RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform. However, the size of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its utility for basic research and therapeutic applications that employ the highly versatile adeno-associated virus (AAV) deliv...

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Veröffentlicht in:Nature
Hauptverfasser: Ran, F. Ann, Cong, Le, Yan, Winston X., Scott, David A., Gootenberg, Jonathan S., Kriz, Andrea J., Zetsche, Bernd, Shalem, Ophir, Wu, Xuebing, Makarova, Kira S., Koonin, Eugene, Sharp, Phillip A., Zhang, Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393360/
https://ncbi.nlm.nih.gov/pubmed/25830891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14299
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