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Engineering of CRISPR-Cas12b for human genome editing
The type-V CRISPR effector Cas12b (formerly known as C2c1) has been challenging to develop for genome editing in human cells, at least in part due to the high temperature requirement of the characterized family members. Here we explore the diversity of the Cas12b family and identify a promising cand...
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| Pubblicato in: | Nat Commun |
|---|---|
| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6342934/ https://ncbi.nlm.nih.gov/pubmed/30670702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08224-4 |
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