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Discovery of YopE Inhibitors by Pharmacophore-Based Virtual Screening and Docking
Gram-negative bacteria Yersinia secrete virulence factors that invade eukaryotic cells via type III secretion system. One particular virulence member, Yersinia outer protein E (YopE), targets Rho family of small GTPases by mimicking regulator GAP protein activity, and its secretion mainly induces cy...
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| Опубликовано в: : | ISRN Bioinform |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Hindawi Publishing Corporation
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4393062/ https://ncbi.nlm.nih.gov/pubmed/25937949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/640518 |
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