Discovery of YopE Inhibitors by Pharmacophore-Based Virtual Screening and Docking

Gram-negative bacteria Yersinia secrete virulence factors that invade eukaryotic cells via type III secretion system. One particular virulence member, Yersinia outer protein E (YopE), targets Rho family of small GTPases by mimicking regulator GAP protein activity, and its secretion mainly induces cy...

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Vydáno v:ISRN Bioinform
Hlavní autoři: Ozbuyukkaya, Gizem, Ozkirimli Olmez, Elif, Ulgen, Kutlu O.
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393062/
https://ncbi.nlm.nih.gov/pubmed/25937949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/640518
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