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Tubulin inhibitors: pharmacophore modeling, virtual screening and molecular docking

AIM: To construct a quantitative pharmacophore model of tubulin inhibitors and to discovery new leads with potent antitumor activities. METHODS: Ligand-based pharmacophore modeling was used to identify the chemical features responsible for inhibiting tubulin polymerization. A set of 26 training comp...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Niu, Miao-miao, Qin, Jing-yi, Tian, Cai-ping, Yan, Xia-fei, Dong, Feng-gong, Cheng, Zheng-qi, Fida, Guissi, Yang, Man, Chen, Haiyan, Gu, Yue-qing
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4088285/
https://ncbi.nlm.nih.gov/pubmed/24909516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.34
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