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Discovery of YopE Inhibitors by Pharmacophore-Based Virtual Screening and Docking
Gram-negative bacteria Yersinia secrete virulence factors that invade eukaryotic cells via type III secretion system. One particular virulence member, Yersinia outer protein E (YopE), targets Rho family of small GTPases by mimicking regulator GAP protein activity, and its secretion mainly induces cy...
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| Publicat a: | ISRN Bioinform |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Hindawi Publishing Corporation
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4393062/ https://ncbi.nlm.nih.gov/pubmed/25937949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/640518 |
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