The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies

BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia characterized by progressive cognitive impairment in the elderly people. The most dramatic abnormalities are those of the cholinergic system. Acetylcholinesterase (AChE) plays a key role in the regulation of the cholinerg...

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Bibliografische gegevens
Hoofdauteurs: Lu, Shin-Hua, Wu, Josephine W, Liu, Hsuan-Liang, Zhao, Jian-Hua, Liu, Kung-Tien, Chuang, Chih-Kuang, Lin, Hsin-Yi, Tsai, Wei-Bor, Ho, Yih
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2011
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036604/
https://ncbi.nlm.nih.gov/pubmed/21251245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-18-8
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