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The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies

BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia characterized by progressive cognitive impairment in the elderly people. The most dramatic abnormalities are those of the cholinergic system. Acetylcholinesterase (AChE) plays a key role in the regulation of the cholinerg...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Lu, Shin-Hua, Wu, Josephine W, Liu, Hsuan-Liang, Zhao, Jian-Hua, Liu, Kung-Tien, Chuang, Chih-Kuang, Lin, Hsin-Yi, Tsai, Wei-Bor, Ho, Yih
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: BioMed Central 2011
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036604/
https://ncbi.nlm.nih.gov/pubmed/21251245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-18-8
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