The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies

BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia characterized by progressive cognitive impairment in the elderly people. The most dramatic abnormalities are those of the cholinergic system. Acetylcholinesterase (AChE) plays a key role in the regulation of the cholinerg...

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Detalhes bibliográficos
Main Authors: Lu, Shin-Hua, Wu, Josephine W, Liu, Hsuan-Liang, Zhao, Jian-Hua, Liu, Kung-Tien, Chuang, Chih-Kuang, Lin, Hsin-Yi, Tsai, Wei-Bor, Ho, Yih
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3036604/
https://ncbi.nlm.nih.gov/pubmed/21251245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-18-8
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