Discovery of YopE Inhibitors by Pharmacophore-Based Virtual Screening and Docking

Gram-negative bacteria Yersinia secrete virulence factors that invade eukaryotic cells via type III secretion system. One particular virulence member, Yersinia outer protein E (YopE), targets Rho family of small GTPases by mimicking regulator GAP protein activity, and its secretion mainly induces cy...

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Bibliographic Details
Published in:ISRN Bioinform
Main Authors: Ozbuyukkaya, Gizem, Ozkirimli Olmez, Elif, Ulgen, Kutlu O.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393062/
https://ncbi.nlm.nih.gov/pubmed/25937949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/640518
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