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Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth
Ras is mutated in up to 30% of cancers, including 90% of pancreatic ductal adenocarcinomas, causing it to be constitutively GTP-bound, and leading to activation of downstream effectors that promote a tumorigenic phenotype. As targeting Ras directly is difficult, there is a significant effort to unde...
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| Publicado no: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4393013/ https://ncbi.nlm.nih.gov/pubmed/25658205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.002 |
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