Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth

Mitochondria undergo fission and fusion to maintain homeostasis, and tumors exhibit the dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRas(G12V) promotes mitochondrial fragmentation and tumor growth through Erk phosphorylation of the mitochondrial fission GTPase Dyna...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Nagdas, Sarbajeet, Kashatus, Jennifer A., Nascimento, Aldo, Hussain, Syed S., Trainor, Riley E., Pollock, Sarah R., Adair, Sara J., Michaels, Alex D., Sesaki, Hiromi, Stelow, Edward B., Bauer, Todd W., Kashatus, David F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6711191/
https://ncbi.nlm.nih.gov/pubmed/31412251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.031
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