Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth

Mitochondria undergo fission and fusion to maintain homeostasis, and tumors exhibit the dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRas(G12V) promotes mitochondrial fragmentation and tumor growth through Erk phosphorylation of the mitochondrial fission GTPase Dyna...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Nagdas, Sarbajeet, Kashatus, Jennifer A., Nascimento, Aldo, Hussain, Syed S., Trainor, Riley E., Pollock, Sarah R., Adair, Sara J., Michaels, Alex D., Sesaki, Hiromi, Stelow, Edward B., Bauer, Todd W., Kashatus, David F.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6711191/
https://ncbi.nlm.nih.gov/pubmed/31412251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.031
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