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Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth
Ras is mutated in up to 30% of cancers, including 90% of pancreatic ductal adenocarcinomas, causing it to be constitutively GTP-bound, and leading to activation of downstream effectors that promote a tumorigenic phenotype. As targeting Ras directly is difficult, there is a significant effort to unde...
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| Publicat a: | Mol Cell |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4393013/ https://ncbi.nlm.nih.gov/pubmed/25658205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.002 |
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