Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth

Ras is mutated in up to 30% of cancers, including 90% of pancreatic ductal adenocarcinomas, causing it to be constitutively GTP-bound, and leading to activation of downstream effectors that promote a tumorigenic phenotype. As targeting Ras directly is difficult, there is a significant effort to unde...

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Опубликовано в: :Mol Cell
Главные авторы: Kashatus, Jennifer A., Nascimento, Aldo, Myers, Lindsey J., Sher, Annie, Byrne, Frances L., Hoehn, Kyle L., Counter, Christopher M., Kashatus, David F.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393013/
https://ncbi.nlm.nih.gov/pubmed/25658205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.002
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