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glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis

The interconversion of cell lineages via transdifferentiation is an adaptive mode of tissue regeneration and an appealing therapeutic target. However, its clinical exploitation is contingent upon the discovery of contextual regulators of cell fate acquisition and maintenance. In murine models of dia...

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Dettagli Bibliografici
Pubblicato in:Development
Autori principali: Ye, Lihua, Robertson, Morgan A., Hesselson, Daniel, Stainier, Didier Y. R., Anderson, Ryan M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392596/
https://ncbi.nlm.nih.gov/pubmed/25852199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.117911
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