Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome

The pathogenesis of atypical hemolytic uremic syndrome (aHUS) is strongly linked to dysregulation of the alternative pathway of the complement system. Mutations in complement genes have been identified in about two-thirds of cases, with 5% to 15% being in C3. In this study, 23 aHUS-associated geneti...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Schramm, Elizabeth C., Roumenina, Lubka T., Rybkine, Tania, Chauvet, Sophie, Vieira-Martins, Paula, Hue, Christophe, Maga, Tara, Valoti, Elisabetta, Wilson, Valerie, Jokiranta, Sakari, Smith, Richard J. H., Noris, Marina, Goodship, Tim, Atkinson, John P., Fremeaux-Bacchi, Veronique
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2015
Assuntos:
Immunobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392009/
https://ncbi.nlm.nih.gov/pubmed/25608561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-609073
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