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Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome

The hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment. Genetic studies demonstrate that heterozygous mutations of membrane cofactor protein (MCP;CD46) predispose to atypical HUS (aHUS), which is not associated with exposure to Shi...

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Main Authors:	Fang, Celia J., Fremeaux-Bacchi, Veronique, Liszewski, M. Kathryn, Pianetti, Gaia, Noris, Marina, Goodship, Timothy H. J., Atkinson, John P.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society of Hematology 2008
נושאים:	Hemostasis, Thrombosis, and Vascular Biology
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2200836/ https://ncbi.nlm.nih.gov/pubmed/17914026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-04-084533
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Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome

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