Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome

The pathogenesis of atypical hemolytic uremic syndrome (aHUS) is strongly linked to dysregulation of the alternative pathway of the complement system. Mutations in complement genes have been identified in about two-thirds of cases, with 5% to 15% being in C3. In this study, 23 aHUS-associated geneti...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Schramm, Elizabeth C., Roumenina, Lubka T., Rybkine, Tania, Chauvet, Sophie, Vieira-Martins, Paula, Hue, Christophe, Maga, Tara, Valoti, Elisabetta, Wilson, Valerie, Jokiranta, Sakari, Smith, Richard J. H., Noris, Marina, Goodship, Tim, Atkinson, John P., Fremeaux-Bacchi, Veronique
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392009/
https://ncbi.nlm.nih.gov/pubmed/25608561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-10-609073
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