Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease

INTRODUCTION: Scurfy mice are deficient in regulatory T cells (Tregs), develop a severe, generalized autoimmune disorder that can affect almost every organ and die at an early age. Some of these manifestations resemble those found in systemic lupus erythematosus (SLE). In addition, active SLE is ass...

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Bibliografiska uppgifter
I publikationen:Arthritis Res Ther
Huvudupphovsmän: Hadaschik, Eva N, Wei, Xiaoying, Leiss, Harald, Heckmann, Britta, Niederreiter, Birgit, Steiner, Günter, Ulrich, Walter, Enk, Alexander H, Smolen, Josef S, Stummvoll, Georg H
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391674/
https://ncbi.nlm.nih.gov/pubmed/25890083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0538-0
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