Role of CD28 in fatal autoimmune disorder in scurfy mice

Scurfy mice develop CD4 T-cell–mediated lymphoproliferative disease leading to death within 4 weeks of age. The scurfy mutation causes loss of function of the foxp3 gene (foxp3(sf)), which is essential for development and maintenance of naturally occurring regulatory CD4 T cells (nTregs). In humans,...

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Autores principales: Singh, Nagendra, Chandler, Phillip R., Seki, Yoichi, Baban, Babak, Takezaki, Mayuko, Kahler, David J., Munn, David H., Larsen, Christian P., Mellor, Andrew L., Iwashima, Makio
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2007
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1939901/
https://ncbi.nlm.nih.gov/pubmed/17463170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-10-054585
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