Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease

INTRODUCTION: Scurfy mice are deficient in regulatory T cells (Tregs), develop a severe, generalized autoimmune disorder that can affect almost every organ and die at an early age. Some of these manifestations resemble those found in systemic lupus erythematosus (SLE). In addition, active SLE is ass...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Hadaschik, Eva N, Wei, Xiaoying, Leiss, Harald, Heckmann, Britta, Niederreiter, Birgit, Steiner, Günter, Ulrich, Walter, Enk, Alexander H, Smolen, Josef S, Stummvoll, Georg H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391674/
https://ncbi.nlm.nih.gov/pubmed/25890083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0538-0
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