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Stochastic Tunneling and Metastable States During the Somatic Evolution of Cancer

Tumors initiate when a population of proliferating cells accumulates a certain number and type of genetic and/or epigenetic alterations. The population dynamics of such sequential acquisition of (epi)genetic alterations has been the topic of much investigation. The phenomenon of stochastic tunneling...

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Bibliografiske detaljer
Udgivet i:Genetics
Main Authors: Ashcroft, Peter, Michor, Franziska, Galla, Tobias
Format: Artigo
Sprog:Inglês
Udgivet: Genetics Society of America 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4391561/
https://ncbi.nlm.nih.gov/pubmed/25624316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.171553
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