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Evolution of Resistance During Clonal Expansion

Acquired drug resistance is a major limitation for cancer therapy. Often, one genetic alteration suffices to confer resistance to an otherwise successful therapy. However, little is known about the dynamics of the emergence of resistant tumor cells. In this article, we consider an exponentially grow...

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Detalhes bibliográficos
Main Authors: Iwasa, Yoh, Nowak, Martin A., Michor, Franziska
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright © 2006 by the Genetics Society of America 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456382/
https://ncbi.nlm.nih.gov/pubmed/16636113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.049791
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