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Genetic instability and clonal expansion

Inactivation of tumor suppressor genes can lead to clonal expansion. We study the evolutionary dynamics of this process and calculate the probability that inactivation of a tumor suppressor gene is preceded by mutations in genes that confer genetic instability. Unstable cells might have a slower rat...

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Bibliografski detalji
Glavni autori: Nowak, Martin A., Michor, Franziska, Iwasa, Yoh
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286117/
https://ncbi.nlm.nih.gov/pubmed/16405914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2005.11.012
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