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The age incidence of chronic myeloid leukemia can be explained by a one-mutation model

Chronic myeloid leukemia (CML) is associated with the Philadelphia chromosome, which arises by a reciprocal translocation between chromosomes 9 and 22 and harbors the BCR-ABL fusion oncogene. It is unknown whether any other mutations are needed for the chronic phase of the disease. The CML incidence...

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Detalhes bibliográficos
Main Authors: Michor, Franziska, Iwasa, Yoh, Nowak, Martin A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1595453/
https://ncbi.nlm.nih.gov/pubmed/17001000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607006103
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