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Suppression of tumorigenesis by the p53 target PUMA
The p53 tumor suppressor regulates diverse antiproliferative processes such that cells acquiring p53 mutations have impaired cell-cycle checkpoints, senescence, apoptosis, and genomic stability. Here, we use stable RNA interference to examine the role of PUMA, a p53 target gene and proapoptotic memb...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2004
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC438977/ https://ncbi.nlm.nih.gov/pubmed/15192153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403286101 |
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