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The ATM–p53 pathway suppresses aneuploidy-induced tumorigenesis
The spindle assembly checkpoint (SAC) is essential for proper sister chromatid segregation. Defects in this checkpoint can lead to chromosome missegregation and aneuploidy. An increasing body of evidence suggests that aneuploidy can play a causal role in tumorigenesis. However, mutant mice that are...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922543/ https://ncbi.nlm.nih.gov/pubmed/20663956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005960107 |
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