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USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis
Most human tumors have abnormal numbers of chromosomes, a condition known as aneuploidy. The mitotic checkpoint is an important mechanism that prevents aneuploidy by restraining the activity of the anaphase-promoting complex (APC). The deubiquitinase USP44 was identified as a key regulator of APC ac...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3533537/ https://ncbi.nlm.nih.gov/pubmed/23187126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63084 |
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