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USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis

Most human tumors have abnormal numbers of chromosomes, a condition known as aneuploidy. The mitotic checkpoint is an important mechanism that prevents aneuploidy by restraining the activity of the anaphase-promoting complex (APC). The deubiquitinase USP44 was identified as a key regulator of APC ac...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Zhang, Ying, Foreman, Oded, Wigle, Dennis A., Kosari, Farhad, Vasmatzis, George, Salisbury, Jeffrey L., van Deursen, Jan, Galardy, Paul J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Clinical Investigation 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533537/
https://ncbi.nlm.nih.gov/pubmed/23187126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63084
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