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USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis

Most human tumors have abnormal numbers of chromosomes, a condition known as aneuploidy. The mitotic checkpoint is an important mechanism that prevents aneuploidy by restraining the activity of the anaphase-promoting complex (APC). The deubiquitinase USP44 was identified as a key regulator of APC ac...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zhang, Ying, Foreman, Oded, Wigle, Dennis A., Kosari, Farhad, Vasmatzis, George, Salisbury, Jeffrey L., van Deursen, Jan, Galardy, Paul J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533537/
https://ncbi.nlm.nih.gov/pubmed/23187126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63084
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