Methyl-Substituted Conformationally Constrained Rexinoid Agonists for the Retinoid X Receptors Demonstrate Improved Efficacy for Cancer Therapy and Prevention

(2E,4E,6Z,8Z)-8-(3’,4’-Dihydro-1’(2H)-naphthalen-1’-ylidene)-3,7-dimethyl-2,3,6-octatrienoinic acid, 9cUAB30, is a selective rexinoid for the retinoid X nuclear receptors (RXR). 9cUAB30 displays substantial chemopreventive capacity with little toxicity and is being translated to the clinic as a nove...

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Publicat a:Bioorg Med Chem
Autors principals: Desphande, Anil, Xia, Gang, Boerma, LeeAnn J., Vines, Kimberly K, Atigadda, Venkatram R., Lobo-Ruppert, Susan, Grubbs, Clinton J., Moeinpour, Fariba L, Smith, Craig D., Christov, Konstantin, Brouillette, Wayne J., Muccio, Donald D.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387854/
https://ncbi.nlm.nih.gov/pubmed/24359708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.11.039
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