Methyl Substitution of a Rexinoid Agonist Improves Potency and Reveals Site of Lipid Toxicity

[Image: see text] (2E,4E,6Z,8E)-8-(3′,4′-Dihydro-1′(2′H)-naphthalen-1′-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid, 9cUAB30, is a selective rexinoid that displays substantial chemopreventive capacity with little toxicity. 4-Methyl-UAB30, an analogue of 9cUAB30, is a potent RXR agonist but caused i...

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Main Authors: Atigadda, Venkatram R., Xia, Gang, Desphande, Anil, Boerma, LeeAnn J., Lobo-Ruppert, Susan, Grubbs, Clinton J., Smith, Craig D., Brouillette, Wayne J., Muccio, Donald D.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216212/
https://ncbi.nlm.nih.gov/pubmed/24801499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5004792
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