Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition

The sterol regulatory element-binding protein (SREBP) and SREBP cleavage-activating protein (SCAP) are central players in the SREBP pathway, which control the cellular lipid homeostasis. SCAP binds to SREBP through their carboxyl (C) domains and escorts SREBP from the endoplasmic reticulum to the Go...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Gong, Xin, Li, Jingxian, Shao, Wei, Wu, Jianping, Qian, Hongwu, Ren, Ruobing, Espenshade, Peter, Yan, Nieng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387560/
https://ncbi.nlm.nih.gov/pubmed/25771684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.32
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