Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization

Sterol regulatory element-binding protein (SREBP) transcription factors are master regulators of cellular lipid homeostasis in mammals and oxygen-responsive regulators of hypoxic adaptation in fungi. SREBP C-terminus binds to the WD40 domain of SREBP cleavage-activating protein (SCAP), which confers...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Gong, Xin, Qian, Hongwu, Shao, Wei, Li, Jingxian, Wu, Jianping, Liu, Jun-Jie, Li, Wenqi, Wang, Hong-Wei, Espenshade, Peter, Yan, Nieng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099872/
https://ncbi.nlm.nih.gov/pubmed/27811944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.123
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