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4-Methyl Sterols Regulate Fission Yeast SREBP-Scap under Low Oxygen and Cell Stress
In fission yeast, orthologs of mammalian SREBP and Scap, called Sre1 and Scp1, monitor oxygen-dependent sterol synthesis as a measure of cellular oxygen supply. Under low oxygen conditions, sterol synthesis is inhibited and Sre1 cleavage is activated. However, the sterol signal for Sre1 activation i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2262954/ https://ncbi.nlm.nih.gov/pubmed/17595166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M701326200 |
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