Inefficient clearance of myelin debris by microglia impairs remyelinating processes

An imbalance between remyelinating and demyelinating rates underlies degenerative processes in demyelinating diseases such as multiple sclerosis. An optimal therapeutic strategy would be to stimulate remyelination while limiting demyelination. Although accumulation of myelin debris impairs remyelina...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Lampron, Antoine, Larochelle, Antoine, Laflamme, Nathalie, Préfontaine, Paul, Plante, Marie-Michèle, Sánchez, Maria Gabriela, Yong, V. Wee, Stys, Peter K., Tremblay, Marie-Ève, Rivest, Serge
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387282/
https://ncbi.nlm.nih.gov/pubmed/25779633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141656
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