TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are critical for the clearance of myelin debris in areas of demyelination, a key step to allow remyelination. TREM2 is expressed...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Acta Neuropathol
Main Authors: Cignarella, Francesca, Filipello, Fabia, Bollman, Bryan, Cantoni, Claudia, Locca, Alberto, Mikesell, Robert, Manis, Melissa, Ibrahim, Adiljan, Deng, Li, Benitez, Bruno A., Cruchaga, Carlos, Licastro, Danilo, Mihindukulasuriya, Kathie, Harari, Oscar, Buckland, Michael, Holtzman, David M., Rosenthal, Arnon, Schwabe, Tina, Tassi, Ilaria, Piccio, Laura
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2020
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498497/
https://ncbi.nlm.nih.gov/pubmed/32772264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02193-z
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