Estrogens Antagonize RUNX2-Mediated Osteoblast-Driven Osteoclastogenesis Through Regulating RANKL Membrane Association

In addition to its thoroughly investigated role in bone formation, the osteoblast master transcription factor RUNX2 also promotes osteoclastogenesis and bone resorption. Here we demonstrate that 17β-estradiol (E2), which is known to attenuate bone turnover in vivo and RUNX2 activity in vitro, strong...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Bone
Prif Awduron: Martin, Anthony, Xiong, Jian, Koromila, Theodora, Ji, Jie S., Chang, Stephanie, Song, Yae S., Miller, Jonathan L., Han, Chun-Ya, Kostenuik, Paul, Krum, Susan A., Chimge, Nyam-Osor, Gabet, Yankel, Frenkel, Baruch
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387095/
https://ncbi.nlm.nih.gov/pubmed/25701138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2015.02.007
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