Estrogens Antagonize RUNX2-Mediated Osteoblast-Driven Osteoclastogenesis Through Regulating RANKL Membrane Association

In addition to its thoroughly investigated role in bone formation, the osteoblast master transcription factor RUNX2 also promotes osteoclastogenesis and bone resorption. Here we demonstrate that 17β-estradiol (E2), which is known to attenuate bone turnover in vivo and RUNX2 activity in vitro, strong...

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Detalhes bibliográficos
Publicado no:Bone
Main Authors: Martin, Anthony, Xiong, Jian, Koromila, Theodora, Ji, Jie S., Chang, Stephanie, Song, Yae S., Miller, Jonathan L., Han, Chun-Ya, Kostenuik, Paul, Krum, Susan A., Chimge, Nyam-Osor, Gabet, Yankel, Frenkel, Baruch
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387095/
https://ncbi.nlm.nih.gov/pubmed/25701138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2015.02.007
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