Estrogens Antagonize RUNX2-Mediated Osteoblast-Driven Osteoclastogenesis Through Regulating RANKL Membrane Association

In addition to its thoroughly investigated role in bone formation, the osteoblast master transcription factor RUNX2 also promotes osteoclastogenesis and bone resorption. Here we demonstrate that 17β-estradiol (E2), which is known to attenuate bone turnover in vivo and RUNX2 activity in vitro, strong...

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Bibliografske podrobnosti
izdano v:Bone
Main Authors: Martin, Anthony, Xiong, Jian, Koromila, Theodora, Ji, Jie S., Chang, Stephanie, Song, Yae S., Miller, Jonathan L., Han, Chun-Ya, Kostenuik, Paul, Krum, Susan A., Chimge, Nyam-Osor, Gabet, Yankel, Frenkel, Baruch
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387095/
https://ncbi.nlm.nih.gov/pubmed/25701138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2015.02.007
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