Estrogens and selective estrogen receptor modulators differentially antagonize Runx2 in ST2 mesenchymal progenitor cells

Estrogens attenuate bone turnover by inhibiting both osteoclasts and osteoblasts, in part through antagonizing Runx2. Apparently conflicting, stimulatory effects in osteoblast lineage cells, however, sway the balance between bone resorption and bone formation in favor of the latter. Consistent with...

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Detalhes bibliográficos
Publicado no:J Steroid Biochem Mol Biol
Main Authors: Amzaleg, Yonatan, Ji, Jie, Kittivanichkul, Donlaporn, Törnqvist, Anna E, Windahl, Sara, Sabag, Elias, Khalid, Aysha B., Sternberg, Hal, West, Michael, Katzenellenbogen, John A., Krum, Susan A., Chimge, Nyam-Osor, Schones, Dustin E., Gabet, Yankel, Ohlsson, Claes, Frenkel, Baruch
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128776/
https://ncbi.nlm.nih.gov/pubmed/29751107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2018.05.002
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