Estrogens and selective estrogen receptor modulators differentially antagonize Runx2 in ST2 mesenchymal progenitor cells

Estrogens attenuate bone turnover by inhibiting both osteoclasts and osteoblasts, in part through antagonizing Runx2. Apparently conflicting, stimulatory effects in osteoblast lineage cells, however, sway the balance between bone resorption and bone formation in favor of the latter. Consistent with...

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Библиографические подробности
Опубликовано в: :J Steroid Biochem Mol Biol
Главные авторы: Amzaleg, Yonatan, Ji, Jie, Kittivanichkul, Donlaporn, Törnqvist, Anna E, Windahl, Sara, Sabag, Elias, Khalid, Aysha B., Sternberg, Hal, West, Michael, Katzenellenbogen, John A., Krum, Susan A., Chimge, Nyam-Osor, Schones, Dustin E., Gabet, Yankel, Ohlsson, Claes, Frenkel, Baruch
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128776/
https://ncbi.nlm.nih.gov/pubmed/29751107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2018.05.002
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