Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

Binding of dsDNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) triggers formation of the metazoan second messenger c[G(2′,5′)pA(3′,5′)p], which binds the signaling protein STING with subsequent activation of the interferon (IFN) pathway. We show that human hSTING(H232) adopts a ‘‘closed’’ conformation u...

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Pubblicato in:Cell
Autori principali: Gao, Pu, Ascano, Manuel, Zillinger, Thomas, Wang, Weiyi, Dai, Peihong, Serganov, Artem A., Gaffney, Barbara L., Shuman, Stewart, Jones, Roger A., Deng, Liang, Hartmann, Gunther, Barchet, Winfried, Tuschl, Thomas, Patel, Dinshaw J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386733/
https://ncbi.nlm.nih.gov/pubmed/23910378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.07.023
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