UHRF1 Is a Sensor for DNA Interstrand Crosslinks and Recruits FANCD2 to Initiate the Fanconi Anemia Pathway

The Fanconi anemia (FA) pathway is critical for the cellular response to toxic DNA interstrand crosslinks (ICLs). Using a biochemical purification strategy, we identified UHRF1 as a protein that specifically interacts with ICLs in vitro and in vivo. Reduction of cellular levels of UHRF1 by RNAi atte...

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Udgivet i:Cell Rep
Main Authors: Liang, Chih-Chao, Zhan, Bao, Yoshikawa, Yasunaga, Haas, Wilhelm, Gygi, Steven P., Cohn, Martin A.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2015
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386029/
https://ncbi.nlm.nih.gov/pubmed/25801034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.02.053
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