UHRF1 Is a Sensor for DNA Interstrand Crosslinks and Recruits FANCD2 to Initiate the Fanconi Anemia Pathway

The Fanconi anemia (FA) pathway is critical for the cellular response to toxic DNA interstrand crosslinks (ICLs). Using a biochemical purification strategy, we identified UHRF1 as a protein that specifically interacts with ICLs in vitro and in vivo. Reduction of cellular levels of UHRF1 by RNAi atte...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Liang, Chih-Chao, Zhan, Bao, Yoshikawa, Yasunaga, Haas, Wilhelm, Gygi, Steven P., Cohn, Martin A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2015
Konular:
Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386029/
https://ncbi.nlm.nih.gov/pubmed/25801034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.02.053
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