Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

Activation of the PERK branch of the unfolded protein response (UPR) in response to protein misfolding within the endoplasmic reticulum (ER) results in the transient repression of protein synthesis, mediated by the phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2α). This...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell Death Dis
Asıl Yazarlar: Halliday, M, Radford, H, Sekine, Y, Moreno, J, Verity, N, le Quesne, J, Ortori, C A, Barrett, D A, Fromont, C, Fischer, P M, Harding, H P, Ron, D, Mallucci, G R
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2015
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385927/
https://ncbi.nlm.nih.gov/pubmed/25741597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.49
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller